| Name | Meaning | Gender | Origin |
|---|
| Sabre | | Unisex | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Selina | Moon | Female | Greek |
| Shadow | Shadow | Unisex | English |
| Shark | | Unisex | Hebrew |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelly | Clearing near a ledge | Unisex | English |
| Sierra | Mountain range | Female | Spanish |
| Sky | Sky | Unisex | Norse |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Soda | A carbonated water. | Unisex | English |
| Sonya | Wisdom | Female | Greek |
| Sophie | Wisdom | Female | Greek |
| Star | Star | Female | Latin |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Suki | To like | Female | Japanese |
| Talia | Dew of God | Female | Hebrew |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tasha | (Christ's) birthday | Female | Latin |
| Taylor | A tailor | Female | English |
| Tempest | Storm | Female | English |
| Tex | Of Texas | Unisex | English |