| Name | Meaning | Gender | Origin |
|---|
| Skittles | | Unisex | Hebrew |
| Sky | Sky | Unisex | Norse |
| Skye | Cloud | Male | Norse |
| Slipper | | Unisex | Hebrew |
| Smokie | | Unisex | Hebrew |
| Snowball | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Sonny | Son | Male | English |
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Sphinx | | Unisex | Hebrew |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spinner | | Unisex | Hebrew |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | English |
| Spud | Slang for potato. | Unisex | English |
| Stan | Meadow that is stony | Male | English |
| Stardust | | Unisex | Hebrew |
| Starlight | | Unisex | Hebrew |
| Sterling | Little star - stellar | Male | English |
| Stetson | Son of Stephen | Male | English |
| Sully | Keen eye | Male | Gaelic |
| Sunday | 7th day of the week | Unisex | English |
| Sunny | Filled with sunlight | Male | English |
| Sunshine | Light from the sun | Unisex | English |
| Sweetie | Sweetheart. | Unisex | English |
| Taco | A folded fried tortilla filled with meat, cheese and spices. | Unisex | English |
| Tango | | Unisex | Hebrew |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |