| Name | Meaning | Gender | Origin |
|---|
| Pumpkin | Large round fruit with orange skin | Unisex | English |
| Queenie | Female ruler | Female | English |
| Rags | | Unisex | Hebrew |
| Rascal | One that is playfully mischievous | Unisex | English |
| Rhianna | Nymph | Female | Welsh |
| Rina | Pet form of names in -rina | Female | English |
| Rose | Rose | Female | Latin |
| Rosie | Rose | Female | Latin |
| Roxy | Star | Female | Persian |
| Rusty | Rusty, full of rust | Unisex | American English |
| Sadie | Princess | Female | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Sara | Princess | Female | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scamp | A mischievous youngster | Unisex | English |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sherry | The plains | Female | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Simba | Lion | Female | Swahili |
| Slim | Slender in proportion to height. | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stumpy | A short, thickset person | Unisex | English |
| Suki | To like | Female | Japanese |
| Sweetie | Sweetheart. | Unisex | English |