| Name | Meaning | Gender | Origin |
|---|
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sara | Princess | Female | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scamp | A mischievous youngster | Unisex | English |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sherry | The plains | Female | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Simba | Lion | Female | Swahili |
| Slim | Slender in proportion to height. | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Squirt | Slang for a small person | Unisex | English |
| Stanley | Meadow that is stony | Male | English |
| Stumpy | A short, thickset person | Unisex | English |
| Suki | To like | Female | Japanese |
| Sweetie | Sweetheart. | Unisex | English |
| Tamara | Palm tree | Female | Hebrew |
| Tammy | Twin | Female | Aramaic |
| Teddy | Gift of God | Male | Greek |
| Tia | Princess Or Crowned One | Female | English |
| Tilly | Powerful battler | Unisex | Germanic |
| Timmy | To honor God, to fear God | Male | Greek |
| Tiny | Extremely small | Unisex | English |
| Toby | God is good | Unisex | Hebrew |