| Name | Meaning | Gender | Origin |
|---|
| Seth | Appointed | Male | Hebrew |
| Shadow | Shadow | Unisex | English |
| Shelly | Clearing near a ledge | Unisex | English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shing | Triumph, victory | Male | Chinese |
| Shorty | Of less than average size | Unisex | English |
| Slim | Slender in proportion to height. | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Sonic | Approaching the speed of sound, fast-paced | Unisex | English |
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Spence | Dispenser: Provider. | Male | English |
| Spider | An eight legged insect | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Squirt | Slang for a small person | Unisex | English |
| Stewie | | Unisex | Hebrew |
| Stumpy | A short, thickset person | Unisex | English |
| Sumati | Pure-minded | Male | Sanskrit |
| Sunny | Filled with sunlight | Male | English |
| Sweetie | Sweetheart. | Unisex | English |
| Sylvester | A forest | Male | Latin |
| Tango | | Unisex | Hebrew |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Ted | Gift of God | Male | Greek |
| Teddy | Gift of God | Male | Greek |
| Terry | Ruler of the people | Unisex | Germanic |
| Tex | Of Texas | Unisex | English |
| Tilly | Powerful battler | Unisex | Germanic |
| Timber | Wood used as a building material. Also timber-wolf. | Unisex | English |