| Name | Meaning | Gender | Origin |
|---|
| Sevati | White coloured plant | Female | Indian |
| Shadow | Shadow | Unisex | English |
| Shanta | The pacified | Female | Sanskrit |
| Sharmila | Protection | Female | Sanskrit |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shelly | Clearing near a ledge | Unisex | English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shing | Triumph, victory | Male | Chinese |
| Shorty | Of less than average size | Unisex | English |
| Silvana | Of the forest | Female | Latin |
| Simba | Lion | Female | Swahili |
| Sissy | Blind | Female | Latin |
| Slim | Slender in proportion to height. | Unisex | English |
| Smita | Happy face | Female | Indian |
| Snoopy | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Sonia | Wisdom | Female | Greek |
| Sonic | Approaching the speed of sound, fast-paced | Unisex | English |
| Sophia | Wisdom | Female | Greek |
| Sophie | Wisdom | Female | Greek |
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Spence | Dispenser: Provider. | Male | English |
| Spider | An eight legged insect | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Squirt | Slang for a small person | Unisex | English |
| Stewie | | Unisex | Hebrew |
| Stumpy | A short, thickset person | Unisex | English |
| Sumati | Pure-minded | Male | Sanskrit |