| Name | Meaning | Gender | Origin |
|---|
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sadie | Princess | Female | Hebrew |
| Sam | He is called god | Male | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sapphire | Beautiful jewel | Female | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Scarlet | Scarlet | Female | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shorty | Of less than average size | Unisex | English |
| Simba | Lion | Female | Swahili |
| Skinny | | Unisex | Hebrew |
| Slim | Slender in proportion to height. | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spider | An eight legged insect | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Squeek | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Storm | Violent weather | Female | English |