| Name | Meaning | Gender | Origin |
|---|
| Rogue | | Unisex | Hebrew |
| Rohan | Ascending | Male | Sanskrit |
| Roman | Roman | Unisex | Latin |
| Romy | Sea dew | Unisex | Latin |
| Ronan | Little seal | Male | Gaelic |
| Rooney | Hero | Male | English |
| Rory | Red king | Male | Gaelic |
| Rowan | Little red one | Male | Gaelic |
| Rudy | Famous wolf | Male | Germanic |
| Rusty | Rusty, full of rust | Unisex | American English |
| Ryan | Little King | Male | Gaelic |
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sage | Aromatic herb | Unisex | English |
| Sam | He is called god | Male | Hebrew |
| Sammy | His name is God | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Scully | Town Crier | Male | English |
| Seamus | Form Of James Supplanter. | Male | English |
| Shadow | Shadow | Unisex | English |
| Shamus | Supplanter | Male | Hebrew |
| Shark | | Unisex | Hebrew |