| Name | Meaning | Gender | Origin |
|---|
| Rosie | Rose | Female | Latin |
| Roxie | Star | Unisex | Persian |
| Roxy | Star | Female | Persian |
| Rusty | Rusty, full of rust | Unisex | American English |
| Ryo | Fact | Unisex | Japanese |
| Sadie | Princess | Female | Hebrew |
| Saffron | From the spice or the colour, yellow | Female | English |
| Saki | Rare blossoming | Unisex | Japanese |
| Sakura | Cherry blossom | Female | Japanese |
| Sam | He is called god | Male | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Sana | Brilliance | Female | Arabic |
| Sara | Princess | Female | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sashi | Moonbeam | Female | Hindu |
| Sassy | Lively and spirited | Unisex | English |
| Savannah | Plateau | Female | Spanish |
| Scarlet | Scarlet | Female | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scrappie | | Unisex | Hebrew |
| Seth | Appointed | Male | Hebrew |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shiori | Bookmark | Unisex | Japanese |
| Shorty | Of less than average size | Unisex | English |
| Simba | Lion | Female | Swahili |
| Slim | Slender in proportion to height. | Unisex | English |
| Soda | A carbonated water. | Unisex | English |