| Name | Meaning | Gender | Origin |
| Bear | Large mammal with large head, bulky body and coarse thick fur | Unisex | English |
| Beast | | Unisex | Hebrew |
| Beastie | | Unisex | Hebrew |
| Beowulf | Bee wolf | Unisex | Germanic |
| Bertha | Famous | Female | Germanic |
| Bruiser | A large heavyset man | Unisex | English |
| Bull | The adult male of certain large animals like cattle and elephants | Unisex | English |
| Bully | An overbearing person, a ruffian | Unisex | English |
| Butch | Masculine in appearance or manner. | Unisex | American English |
| Chewy | Needing chewing. | Unisex | English |
| Cujo | | Unisex | Hebrew |
| Denali | The great one | Female | Native American |
| Diesel | | Unisex | Hebrew |
| Fluffy | Covered with fluff, Soft, light and airy. | Female | English |
| Fuzzy | | Unisex | Hebrew |
| Goliath | Tall | Unisex | Hebrew |
| Hades | World of the dead or hell. | Unisex | Greek |
| Hagrid | | Unisex | Hebrew |
| Jupiter | Father god | Unisex | Latin |
| Kitty | Pure | Female | Greek |
| Magnum | A large type of wine bottle. | Unisex | English |
| Mittens | | Unisex | Hebrew |
| Moose | Largest member of the deer family. Moose have heavy brown bodies with humped shoulders and broad antlers. | Unisex | English |
| Peanut | Edible nuts eaten raw or roasted. | Unisex | English |
| Rambo | | Unisex | Hebrew |
| Rhino | | Unisex | Hebrew |
| Shredder | | Unisex | Hebrew |
| Slim | Slender in proportion to height. | Unisex | English |
| Snowball | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |