| Name | Meaning | Gender | Origin |
|---|
| Sandy | Defending men | Male | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Savannah | Plateau | Female | Spanish |
| Schnapps | Variety of strong liquor usually associated with Holland | Unisex | English |
| Scout | Observer | Unisex | American English |
| Sebastian | Man from Sebaste | Male | Latin |
| Serge | Servant | Male | Latin |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Sherlock | With cropped hair | Male | English |
| Silvia | Wooded | Female | Latin |
| Simba | Lion | Female | Swahili |
| Smoky | | Unisex | Hebrew |
| Snickers | A brand of candy bar. | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Speedy | Rapid motion, swift. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Starr | Star | Female | Latin |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Taro | Plump son | Male | Japanese |
| Taz | Wild Animal, Thrid Born | Unisex | American |
| Teddy | Gift of God | Male | Greek |
| Thelma | Will | Female | Literary |
| Thor | Thunder | Male | Norse |
| Tia | Princess Or Crowned One | Female | English |
| Tickles | | Unisex | Hebrew |
| Tilly | Powerful battler | Unisex | Germanic |