| Name | Meaning | Gender | Origin |
|---|
| Rocket | To move swiftly and powerfully | Unisex | English |
| Rogue | | Unisex | Hebrew |
| Roman | Roman | Unisex | Latin |
| Rowdy | Boisterous. Western Nickname. | Unisex | English |
| Rumor | Hood | Unisex | English |
| Rusty | Rusty, full of rust | Unisex | American English |
| Ryo | Fact | Unisex | Japanese |
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sage | Aromatic herb | Unisex | English |
| Saki | Rare blossoming | Unisex | Japanese |
| Salem | Secure, peace | Unisex | Arabic |
| Sammy | His name is God | Unisex | Hebrew |
| Sampson | Sun | Unisex | Hebrew |
| Sanyu | Joyful | Unisex | African |
| Sarge | Noncommissioned Army or Air Force rank | Unisex | English |
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Sedona | | Unisex | Hebrew |
| Seiko | Sincere child | Unisex | Japanese |
| Shadow | Shadow | Unisex | English |
| Shark | | Unisex | Hebrew |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shiori | Bookmark | Unisex | Japanese |
| Sky | Sky | Unisex | Norse |