| Name | Meaning | Gender | Origin |
|---|
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Satoko | Wise child | Female | Japanese |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Savanna | Plateau | Female | Spanish |
| Scarlet | Scarlet | Female | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Sedona | | Unisex | Hebrew |
| Seiichi | Sincere one | Male | Japanese |
| Seiko | Sincere child | Unisex | Japanese |
| Serena | Composed | Female | Latin |
| Shadow | Shadow | Unisex | English |
| Shalom | Well-being | Female | Hebrew |
| Shark | | Unisex | Hebrew |
| Shasta | Name of a Native American tribe | Female | Native American |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shika | Excellent intention | Female | Japanese |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shin | Belief, faith, trust | Female | Korean |
| Shinichi | One truth | Male | Japanese |
| Shiori | Bookmark | Unisex | Japanese |
| Shoichi | First Son Of Sho | Male | Japanese |
| Shuichi | One lord | Male | Japanese |
| Sierra | Mountain range | Female | Spanish |
| Silver | Silver (the metal or colour) | Male | English |
| Simba | Lion | Female | Swahili |