| Name | Meaning | Gender | Origin |
|---|
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Santiago | Saint James | Male | Spanish |
| Sargent | A Squire | Male | English |
| Scooby | | Unisex | Hebrew |
| Seymour | Moor | Male | Latin |
| Shade | Sweetly singing | Unisex | African |
| Shaggy | Bushy and matted (hair), unkempt. | Unisex | English |
| Sheldon | Protected hill | Male | English |
| Shilo | Gift for him | Unisex | Hebrew |
| Shiloh | Gift for him | Unisex | Hebrew |
| Sidney | Wide meadow | Male | English |
| Sigmund | Protector | Male | German |
| Simeon | Sign | Male | English |
| Skip | Master of a Ship | Male | American English |
| Smoky | | Unisex | Hebrew |
| Snoopy | | Unisex | Hebrew |
| Socrates | Uncertain meaning | Male | Greek |
| Solomon | Peace | Male | Hebrew |
| Spencer | Someone who gives out goods | Male | French |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Steve | Crown | Male | Greek |
| Stubby | | Unisex | Hebrew |
| Ted | Gift of God | Male | Greek |
| Teddy | Gift of God | Male | Greek |
| Thaddeus | Uncertain, perhaps praised or heart | Male | Aramaic |
| Theron | Hunter | Male | Greek |
| Thomas | Twin | Male | Aramaic |
| Thornton | Thorn bush enclosure or settlement | Male | English |
| Timmy | To honor God, to fear God | Male | Greek |