| Name | Meaning | Gender | Origin |
|---|
| Prudence | Provident | Female | Latin |
| Prue | Provident | Female | Latin |
| Psycho | | Unisex | Hebrew |
| Pumpkin | Large round fruit with orange skin | Unisex | English |
| Rat | | Unisex | Hebrew |
| Ren | Water lily | Female | Japanese |
| Rhiannon | Nymph | Female | Welsh |
| Roman | Roman | Unisex | Latin |
| Rosemary | Sea dew | Female | Latin |
| Rowena | White Or Comely | Female | English |
| Rune | Rune, secret lore | Unisex | Norse |
| Rusty | Rusty, full of rust | Unisex | American English |
| Sabrina | A Welsh river name | Female | Gaelic |
| Salem | Secure, peace | Unisex | Arabic |
| Sally | Princess | Female | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Scarlett | Scarlet | Female | English |
| Scorpio | Scorpion | Unisex | English |
| Selene | Moon | Female | Greek |
| Serafina | From seraphim, meaning fiery ones | Female | Latin |
| Shadow | Shadow | Unisex | English |
| Skylar | Guarded | Female | Dutch |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snickers | A brand of candy bar. | Unisex | English |
| Sooty | Covered with soot | Unisex | English |
| Spider | An eight legged insect | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Spooky | | Unisex | Hebrew |
| Storm | Violent weather | Female | English |