| Name | Meaning | Gender | Origin |
|---|
| Poppy | Poppy flower | Female | English |
| Princess | Royal son | Female | English |
| Rain | Rain | Female | English |
| Rambo | | Unisex | Hebrew |
| Rogue | | Unisex | Hebrew |
| Roman | Roman | Unisex | Latin |
| Rosie | Rose | Female | Latin |
| Roxy | Star | Female | Persian |
| Ruby | Red | Female | Latin |
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sadie | Princess | Female | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Sampson | Sun | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Sequoia | Large Tree | Female | Native American |
| Shelby | A place where willows grow | Female | American English |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Sophie | Wisdom | Female | Greek |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Sweetie | Sweetheart. | Unisex | English |
| Tai | Big | Unisex | Chinese |