| Name | Meaning | Gender | Origin |
|---|
| Sabre | | Unisex | Hebrew |
| Sadie | Princess | Female | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Saphire | Beautiful jewel | Unisex | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Saul | Responded | Male | Hebrew |
| Senta | Conquering | Female | Latin |
| Serilda | Armored Battle Maiden | Female | English |
| Shark | | Unisex | Hebrew |
| Shasta | Name of a Native American tribe | Female | Native American |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sierra | Mountain range | Female | Spanish |
| Silvester | A forest | Male | Latin |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Stefan | Crown | Male | Greek |
| Stein | Stone | Male | Germanic |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sun | Goodness | Female | Korean |
| Suzanne | Lily | Female | Hebrew |
| Tab | Brilliant | Male | English |
| Talon | A claw | Male | English |