| Name | Meaning | Gender | Origin |
|---|
| Rupert | Bright fame | Male | English |
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sadie | Princess | Female | Hebrew |
| Sam | He is called god | Male | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Saphire | Beautiful jewel | Unisex | Greek |
| Sara | Princess | Female | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Saskia | Saxon woman | Female | Dutch |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Selma | Helmet of God | Female | German |
| Seth | Appointed | Male | Hebrew |
| Shark | | Unisex | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sierra | Mountain range | Female | Spanish |
| Sigmund | Protector | Male | German |
| Simon | Listening | Male | Hebrew |
| Snapper | | Unisex | Hebrew |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Solomon | Peace | Male | Hebrew |
| Sooty | Covered with soot | Unisex | English |
| Sophie | Wisdom | Female | Greek |