| Name | Meaning | Gender | Origin |
|---|
| Rags | | Unisex | Hebrew |
| Ralph | Wolf council | Male | Germanic |
| Rambo | | Unisex | Hebrew |
| Reba | To tie | Female | Hebrew |
| Rebecca | To tie | Female | Hebrew |
| Reggie | Ruler with counsel | Unisex | Germanic |
| Rina | Pet form of names in -rina | Female | English |
| Rogue | | Unisex | Hebrew |
| Rolo | Burmese | Unisex | English |
| Rose | Rose | Female | Latin |
| Rosie | Rose | Female | Latin |
| Roxy | Star | Female | Persian |
| Ruby | Red | Female | Latin |
| Rufus | Red | Male | Latin |
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sadie | Princess | Female | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Saskia | Saxon woman | Female | Dutch |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Skye | Cloud | Male | Norse |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Soda | A carbonated water. | Unisex | English |
| Sooty | Covered with soot | Unisex | English |