| Name | Meaning | Gender | Origin |
|---|
| Rylee | Rye clearing | Unisex | English |
| Sam | He is called god | Male | Hebrew |
| Sammy | His name is God | Unisex | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scully | Town Crier | Male | English |
| Shadow | Shadow | Unisex | English |
| Shorty | Of less than average size | Unisex | English |
| Slim | Slender in proportion to height. | Unisex | English |
| Sloan | Fighter | Male | American English |
| Sloane | Fighter | Unisex | American English |
| Sparky | Animated, lively. | Unisex | English |
| Spencer | Someone who gives out goods | Male | French |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Squirt | Slang for a small person | Unisex | English |
| Stumpy | A short, thickset person | Unisex | English |
| Sunny | Filled with sunlight | Male | English |
| Sweetie | Sweetheart. | Unisex | English |
| Teddy | Gift of God | Male | Greek |
| Tierney | Lordly, noble | Male | Gaelic |
| Tiny | Extremely small | Unisex | English |
| Tipper | Nickname And Variant Of The Irish Name Tabar Meaning A Well. | Unisex | English |
| Toby | God is good | Unisex | Hebrew |
| Toffee | A hard brown, chewy candy | Unisex | English |
| Tootsie | A girl or young woman. | Unisex | English |
| Tucker | Someone who folds cloth | Male | English |
| Tudor | Ruler of the people | Male | Germanic |
| Twiggy | | Unisex | Hebrew |
| Tynan | Dark | Unisex | English |