| Name | Meaning | Gender | Origin |
|---|
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sammy | His name is God | Unisex | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scamper | | Unisex | Hebrew |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Scratch | | Unisex | Hebrew |
| Shadow | Shadow | Unisex | English |
| Shaka | | Unisex | Hebrew |
| Skittles | | Unisex | Hebrew |
| Sleepy | | Unisex | Hebrew |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Smudge | A blotch or smear | Unisex | English |
| Snicker | | Unisex | Hebrew |
| Sniff | A short inhale through the nose. To savour or investigate a smell. | Unisex | English |
| Snowball | | Unisex | Hebrew |
| Spanky | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Speckles | | Unisex | Hebrew |
| Speedy | Rapid motion, swift. | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Squeaky | | Unisex | Hebrew |
| Squirrel | | Unisex | Hebrew |
| Stripe | | Unisex | Hebrew |
| Stripes | | Unisex | Hebrew |
| Sundance | | Unisex | Hebrew |