| Name | Meaning | Gender | Origin |
|---|
| Scratch | | Unisex | Hebrew |
| Serena | Composed | Female | Latin |
| Shadow | Shadow | Unisex | English |
| Shaka | | Unisex | Hebrew |
| Shannon | God is gracious | Female | Hebrew |
| Sheba | Daughter of an oath | Female | Hebrew |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Skittles | | Unisex | Hebrew |
| Sleepy | | Unisex | Hebrew |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Smudge | A blotch or smear | Unisex | English |
| Snicker | | Unisex | Hebrew |
| Sniff | A short inhale through the nose. To savour or investigate a smell. | Unisex | English |
| Snowball | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Spanky | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Speckles | | Unisex | Hebrew |
| Speedy | Rapid motion, swift. | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Squeaky | | Unisex | Hebrew |
| Squirrel | | Unisex | Hebrew |
| Stella | Star | Female | Latin |
| Stripe | | Unisex | Hebrew |
| Stripes | | Unisex | Hebrew |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sundance | | Unisex | Hebrew |