| Name | Meaning | Gender | Origin |
|---|
| Sally | Princess | Female | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Scarlett | Scarlet | Female | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Shilo | Gift for him | Unisex | Hebrew |
| Shiloh | Gift for him | Unisex | Hebrew |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Sofia | Wisdom | Female | Greek |
| Sophia | Wisdom | Female | Greek |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spencer | Someone who gives out goods | Male | French |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Spud | Slang for potato. | Unisex | English |
| Stella | Star | Female | Latin |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Tanner | Tanner | Male | English |
| Ted | Gift of God | Male | Greek |
| Teddy | Gift of God | Male | Greek |
| Tilly | Powerful battler | Unisex | Germanic |
| Toby | God is good | Unisex | Hebrew |
| Trixie | Voyager through life | Female | Latin |
| Trudy | Strength of the spear | Female | Germanic |
| Ulysses | Walker | Male | Greek |
| Victoria | Conqueror | Female | Latin |
| Violet | Violet | Female | Latin |
| Vivian | Alive | Female | Latin |