| Name | Meaning | Gender | Origin |
|---|
| Smoky | | Unisex | Hebrew |
| Snowball | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Sonic | Approaching the speed of sound, fast-paced | Unisex | English |
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Spartacus | From the city of Sparta | Unisex | English |
| Sphinx | | Unisex | Hebrew |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spinner | | Unisex | Hebrew |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | English |
| Spud | Slang for potato. | Unisex | English |
| Squeaky | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Stardust | | Unisex | Hebrew |
| Starlight | | Unisex | Hebrew |
| Stevie | Crown | Unisex | Greek |
| Stumpy | A short, thickset person | Unisex | English |
| Sunday | 7th day of the week | Unisex | English |
| Sunshine | Light from the sun | Unisex | English |
| Suzie | Lily | Unisex | Hebrew |
| Sweetie | Sweetheart. | Unisex | English |
| Taco | A folded fried tortilla filled with meat, cheese and spices. | Unisex | English |
| Tamale | | Unisex | Hebrew |
| Tango | | Unisex | Hebrew |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tanker | | Unisex | Hebrew |
| Tarzan | White skin | Unisex | Literary |