| Name | Meaning | Gender | Origin |
|---|
| Shamrock | | Unisex | Hebrew |
| Shark | | Unisex | Hebrew |
| Shay | Supplanter | Male | Hebrew |
| Sherlock | With cropped hair | Male | English |
| Shorty | Of less than average size | Unisex | English |
| Sigma | | Unisex | Hebrew |
| Silver | Silver (the metal or colour) | Male | English |
| Skittles | | Unisex | Hebrew |
| Sky | Sky | Unisex | Norse |
| Skye | Cloud | Male | Norse |
| Slim | Slender in proportion to height. | Unisex | English |
| Smokie | | Unisex | Hebrew |
| Smoky | | Unisex | Hebrew |
| Snowball | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Solomon | Peace | Male | Hebrew |
| Sonic | Approaching the speed of sound, fast-paced | Unisex | English |
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Spartacus | From the city of Sparta | Unisex | English |
| Spencer | Someone who gives out goods | Male | French |
| Sphinx | | Unisex | Hebrew |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spinner | | Unisex | Hebrew |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | English |
| Spud | Slang for potato. | Unisex | English |
| Squeaky | | Unisex | Hebrew |