| Name | Meaning | Gender | Origin |
|---|
| Shadow | Shadow | Unisex | English |
| Shen | Spirit, deep though | Male | Chinese |
| Sheng | Triumph, victory | Male | Chinese |
| Shing | Triumph, victory | Male | Chinese |
| Shorty | Of less than average size | Unisex | English |
| Silk | | Unisex | Hebrew |
| Silver | Silver (the metal or colour) | Male | English |
| Simon | Listening | Male | Hebrew |
| Skittles | | Unisex | Hebrew |
| Slim | Slender in proportion to height. | Unisex | English |
| Snickers | A brand of candy bar. | Unisex | English |
| Snowball | | Unisex | Hebrew |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Speckles | | Unisex | Hebrew |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Sprinkles | | Unisex | Hebrew |
| Squeaky | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Stinky | | Unisex | Hebrew |
| Stumpy | A short, thickset person | Unisex | English |
| Sweetie | Sweetheart. | Unisex | English |
| Taboo | | Unisex | Hebrew |
| Tango | | Unisex | Hebrew |
| Tao | Apple | Male | Vietnamese |
| Taz | Wild Animal, Thrid Born | Unisex | American |
| Ted | Gift of God | Male | Greek |
| Teddy | Gift of God | Male | Greek |
| Tickles | | Unisex | Hebrew |