| Name | Meaning | Gender | Origin |
|---|
| Sandy | Defending men | Male | Greek |
| Sarge | Noncommissioned Army or Air Force rank | Unisex | English |
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Sassy | Lively and spirited | Unisex | English |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scar | From The Lion King | Unisex | English |
| Shadow | Shadow | Unisex | English |
| Shark | | Unisex | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Skittles | | Unisex | Hebrew |
| Sky | Sky | Unisex | Norse |
| Slim | Slender in proportion to height. | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Speedy | Rapid motion, swift. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Squeaky | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Stumpy | A short, thickset person | Unisex | English |
| Sweetie | Sweetheart. | Unisex | English |
| Taco | A folded fried tortilla filled with meat, cheese and spices. | Unisex | English |
| Tanker | | Unisex | Hebrew |
| Teddy | Gift of God | Male | Greek |
| Terminator | | Unisex | Hebrew |
| Tinkerbell | | Unisex | Hebrew |
| Tiny | Extremely small | Unisex | English |
| Tito | Giant | Unisex | Latin |
| Toby | God is good | Unisex | Hebrew |
| Tootsie | A girl or young woman. | Unisex | English |
| Trojan | | Unisex | Hebrew |