| Name | Meaning | Gender | Origin |
|---|
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sabrina | A Welsh river name | Female | Gaelic |
| Sadie | Princess | Female | Hebrew |
| Saffron | From the spice or the colour, yellow | Female | English |
| Sage | Aromatic herb | Unisex | English |
| Sailor | Sailor | Unisex | English |
| Sammy | His name is God | Unisex | Hebrew |
| Sampson | Sun | Unisex | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scarlett | Scarlet | Female | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Shasta | Name of a Native American tribe | Female | Native American |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Sienna | Reddish orange-brown | Female | Italian |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Star | Star | Female | Latin |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Suki | To like | Female | Japanese |
| Susan | Lily | Female | Hebrew |
| Sweetie | Sweetheart. | Unisex | English |