| Name | Meaning | Gender | Origin |
|---|
| Sergio | Servant | Male | Latin |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shorty | Of less than average size | Unisex | English |
| Sienna | Reddish orange-brown | Female | Italian |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Simone | Listening | Female | Hebrew |
| Skittles | | Unisex | Hebrew |
| Sky | Sky | Unisex | Norse |
| Slim | Slender in proportion to height. | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Snoop | To pry into the private affairs of others | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Sofia | Wisdom | Female | Greek |
| Sonya | Wisdom | Female | Greek |
| Sophia | Wisdom | Female | Greek |
| Sophie | Wisdom | Female | Greek |
| Sparkles | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Sparrow | A bird | Female | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Squirt | Slang for a small person | Unisex | English |
| Starla | Star | Unisex | Latin |
| Steffi | Crown | Female | Greek |
| Stella | Star | Female | Latin |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sushi | Raw fish. | Unisex | English |