| Name | Meaning | Gender | Origin |
|---|
| Skip | Master of a Ship | Male | American English |
| Skipper | Master of a Ship | Male | American English |
| Sky | Sky | Unisex | Norse |
| Skylar | Guarded | Female | Dutch |
| Smiley | | Unisex | Hebrew |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snake | | Unisex | Hebrew |
| Solo | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Spanky | | Unisex | Hebrew |
| Spider | An eight legged insect | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Spud | Slang for potato. | Unisex | English |
| Steve | Crown | Male | Greek |
| Stinky | | Unisex | Hebrew |
| Sue | Lily | Female | Hebrew |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sunny | Filled with sunlight | Male | English |
| Suzy | Lily | Female | Hebrew |
| Talon | A claw | Male | English |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Taryn | King Of Rocky Hill. Variant Of Tarynn. | Female | American English |
| Tarzan | White skin | Unisex | Literary |
| Taz | Wild Animal, Thrid Born | Unisex | American |
| Tempest | Storm | Female | English |
| Tex | Of Texas | Unisex | English |
| Thunder | Stormy Tempered | Unisex | English |
| Tic | | Unisex | Hebrew |
| Tiger | Tiger | Unisex | English |
| Tiny | Extremely small | Unisex | English |