| Name | Meaning | Gender | Origin |
|---|
| Ruby | Red | Female | Latin |
| Rusty | Rusty, full of rust | Unisex | American English |
| Sadie | Princess | Female | Hebrew |
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Sapphire | Beautiful jewel | Female | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Savannah | Plateau | Female | Spanish |
| Scarlet | Scarlet | Female | English |
| Schnapps | Variety of strong liquor usually associated with Holland | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Sela | Rock | Female | Hebrew |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shorty | Of less than average size | Unisex | English |
| Simba | Lion | Female | Swahili |
| Skippy | Master of a Ship | Unisex | American English |
| Slim | Slender in proportion to height. | Unisex | English |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Steffie | Crowned | Female | English |
| Stumpy | A short, thickset person | Unisex | English |
| Susan | Lily | Female | Hebrew |
| Suzie | Lily | Unisex | Hebrew |
| Sweetie | Sweetheart. | Unisex | English |