| Name | Meaning | Gender | Origin |
|---|
| Scout | Observer | Unisex | American English |
| Sela | Rock | Female | Hebrew |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shorty | Of less than average size | Unisex | English |
| Simba | Lion | Female | Swahili |
| Skippy | Master of a Ship | Unisex | American English |
| Slim | Slender in proportion to height. | Unisex | English |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Squirt | Slang for a small person | Unisex | English |
| Steffie | Crowned | Female | English |
| Stumpy | A short, thickset person | Unisex | English |
| Susan | Lily | Female | Hebrew |
| Suzie | Lily | Unisex | Hebrew |
| Sweetie | Sweetheart. | Unisex | English |
| Swiper | | Unisex | Hebrew |
| Taffy | Beloved | Female | Welsh |
| Tamika | People | Female | American English |
| Tasha | (Christ's) birthday | Female | Latin |
| Tatum | Tate's homestead | Female | English |
| Ted | Gift of God | Male | Greek |
| Teddy | Gift of God | Male | Greek |
| Tegan | Beautiful | Male | Welsh |
| Tinkerbell | | Unisex | Hebrew |
| Tiny | Extremely small | Unisex | English |
| Toby | God is good | Unisex | Hebrew |