| Name | Meaning | Gender | Origin |
|---|
| Sassy | Lively and spirited | Unisex | English |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Shade | Sweetly singing | Unisex | African |
| Shadow | Shadow | Unisex | English |
| Shorty | Of less than average size | Unisex | English |
| Sid | Wide meadow | Male | English |
| Sidney | Wide meadow | Male | English |
| Snickers | A brand of candy bar. | Unisex | English |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Stormy | Violent weather | Unisex | English |
| Sunshine | Light from the sun | Unisex | English |
| Sweet | | Unisex | Hebrew |
| Talon | A claw | Male | English |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tanker | | Unisex | Hebrew |
| Tarzan | White skin | Unisex | Literary |
| T-bone | A thick steak containing a T shaped bone. | Unisex | English |
| Teddy | Gift of God | Male | Greek |
| Tex | Of Texas | Unisex | English |
| Thunder | Stormy Tempered | Unisex | English |
| Titus | Of The Giants | Male | Latin |
| Tootsie | A girl or young woman. | Unisex | English |
| Trojan | | Unisex | Hebrew |
| Trouble | A cause of disturbance or difficulty. | Unisex | English |
| Truman | Faithful man | Male | English |
| Tucker | Someone who folds cloth | Male | English |
| Tulip | | Unisex | Hebrew |