| Name | Meaning | Gender | Origin |
|---|
| Roman | Roman | Unisex | Latin |
| Roxie | Star | Unisex | Persian |
| Sasha | Defending men | Unisex | Greek |
| Sausage | Chopped meat stuffed into a prepared casing and cooked. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Skittles | | Unisex | Hebrew |
| Sky | Sky | Unisex | Norse |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snickers | A brand of candy bar. | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Speckles | | Unisex | Hebrew |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Sprinkles | | Unisex | Hebrew |
| Stormy | Violent weather | Unisex | English |
| Streak | | Unisex | Hebrew |
| Stripe | | Unisex | Hebrew |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Taz | Wild Animal, Thrid Born | Unisex | American |
| Tiger | Tiger | Unisex | English |
| Tigger | From Winnie the Pooh | Unisex | English |
| Timber | Wood used as a building material. Also timber-wolf. | Unisex | English |
| Toby | God is good | Unisex | Hebrew |
| Trix | Blessed Traveller | Unisex | English |
| Tuppence | British for two pence (coins) | Unisex | English |
| Twinkle | | Unisex | Hebrew |
| Twix | Brand of chocolate bar. | Unisex | English |