| Name | Meaning | Gender | Origin |
|---|
| Sandy | Defending men | Male | Greek |
| Sarge | Noncommissioned Army or Air Force rank | Unisex | English |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scot | From Scotland: A Gael. Diminutive Of Scott. | Male | English |
| Scott | Painted warrior | Male | English |
| Scout | Observer | Unisex | American English |
| Selby | A place where willows grow | Female | American English |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shona | God is gracious | Female | Hebrew |
| Simba | Lion | Female | Swahili |
| Skye | Cloud | Male | Norse |
| Smoky | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Stone | Stone | Male | English |
| Sue | Lily | Female | Hebrew |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sunny | Filled with sunlight | Male | English |
| Tam | Twin | Female | Aramaic |
| Tammy | Twin | Female | Aramaic |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Taran | Heaven | Unisex | Indian |
| Tasha | (Christ's) birthday | Female | Latin |
| Teddy | Gift of God | Male | Greek |