| Name | Meaning | Gender | Origin |
|---|
| Rory | Red king | Male | Gaelic |
| Rudy | Famous wolf | Male | Germanic |
| Rufus | Red | Male | Latin |
| Rusty | Rusty, full of rust | Unisex | American English |
| Sable | Sable (black) | Unisex | English |
| Sabre | | Unisex | Hebrew |
| Sam | He is called god | Male | Hebrew |
| Sammy | His name is God | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Sawyer | One who saws wood | Male | English |
| Scamp | A mischievous youngster | Unisex | English |
| Scamper | | Unisex | Hebrew |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Shelley | Clearing near a ledge | Male | English |
| Skye | Cloud | Male | Norse |
| Smoky | | Unisex | Hebrew |
| Snowball | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | English |
| Sunny | Filled with sunlight | Male | English |
| Taboo | | Unisex | Hebrew |
| Talon | A claw | Male | English |