| Name | Meaning | Gender | Origin |
|---|
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Sawyer | One who saws wood | Male | English |
| Scamp | A mischievous youngster | Unisex | English |
| Scamper | | Unisex | Hebrew |
| Scarlet | Scarlet | Female | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shelley | Clearing near a ledge | Male | English |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Skye | Cloud | Male | Norse |
| Smoky | | Unisex | Hebrew |
| Snowball | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | English |
| Storm | Violent weather | Female | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sun | Goodness | Female | Korean |
| Sunny | Filled with sunlight | Male | English |