| Name | Meaning | Gender | Origin |
|---|
| Samantha | Listener | Female | Aramaic |
| Sammy | His name is God | Unisex | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Shelby | A place where willows grow | Female | American English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shorty | Of less than average size | Unisex | English |
| Skylar | Guarded | Female | Dutch |
| Slim | Slender in proportion to height. | Unisex | English |
| Sly | A forest | Unisex | Latin |
| Snoopy | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stella | Star | Female | Latin |
| Stumpy | A short, thickset person | Unisex | English |
| Sweetie | Sweetheart. | Unisex | English |
| Taffy | Beloved | Female | Welsh |
| Tango | | Unisex | Hebrew |
| Taz | Wild Animal, Thrid Born | Unisex | American |
| Telly | Wise, Best | Unisex | Greek |
| Tess | Harvester | Female | Greek |
| Tilly | Powerful battler | Unisex | Germanic |
| Tiny | Extremely small | Unisex | English |
| Toby | God is good | Unisex | Hebrew |
| Tootsie | A girl or young woman. | Unisex | English |
| Trigger | | Unisex | Hebrew |
| Twiggy | | Unisex | Hebrew |