| Name | Meaning | Gender | Origin |
|---|
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scarlet | Scarlet | Female | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Shaniqua | Gift Of God | Female | African |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shredder | | Unisex | Hebrew |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Simon | Listening | Male | Hebrew |
| Skyler | Guarded | Unisex | Dutch |
| Smoky | | Unisex | Hebrew |
| Snoopy | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Squirt | Slang for a small person | Unisex | English |
| Storm | Violent weather | Female | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sun | Goodness | Female | Korean |
| Talon | A claw | Male | English |
| Taryn | King Of Rocky Hill. Variant Of Tarynn. | Female | American English |
| Tasha | (Christ's) birthday | Female | Latin |
| Teddy | Gift of God | Male | Greek |
| Tempest | Storm | Female | English |