| Name | Meaning | Gender | Origin |
|---|
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scamp | A mischievous youngster | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Serrano | | Unisex | Hebrew |
| Shadow | Shadow | Unisex | English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Skippy | Master of a Ship | Unisex | American English |
| Sly | A forest | Unisex | Latin |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Sprinkles | | Unisex | Hebrew |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Starlight | | Unisex | Hebrew |
| Stevie | Crown | Unisex | Greek |
| Suede | Swedish | Unisex | English |
| Sushi | Raw fish. | Unisex | English |
| Tango | | Unisex | Hebrew |
| Taz | Wild Animal, Thrid Born | Unisex | American |
| Tex | Of Texas | Unisex | English |
| Thunder | Stormy Tempered | Unisex | English |
| Titan | Powerful big man | Unisex | Greek |
| Toby | God is good | Unisex | Hebrew |
| Uhura | After the female character in Star Trek | Unisex | English |
| Vegas | | Unisex | Hebrew |
| Woodstock | | Unisex | Hebrew |
| Yoda | | Unisex | Hebrew |