| Name | Meaning | Gender | Origin |
|---|
| Sampson | Sun | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scamp | A mischievous youngster | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Sebastian | Man from Sebaste | Male | Latin |
| Serrano | | Unisex | Hebrew |
| Shadow | Shadow | Unisex | English |
| Shiloh | Gift for him | Unisex | Hebrew |
| Sidney | Wide meadow | Male | English |
| Simon | Listening | Male | Hebrew |
| Skipper | Master of a Ship | Male | American English |
| Skippy | Master of a Ship | Unisex | American English |
| Skye | Cloud | Male | Norse |
| Slade | Valley | Male | English |
| Sly | A forest | Unisex | Latin |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Solomon | Peace | Male | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Spencer | Someone who gives out goods | Male | French |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Sprinkles | | Unisex | Hebrew |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Starlight | | Unisex | Hebrew |
| Stevie | Crown | Unisex | Greek |