| Name | Meaning | Gender | Origin |
|---|
| Shanta | The pacified | Female | Sanskrit |
| Shari | The plains | Female | Hebrew |
| Shasta | Name of a Native American tribe | Female | Native American |
| Shayla | Blind | Female | Latin |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sheri | The plains | Female | Hebrew |
| Shiloh | Gift for him | Unisex | Hebrew |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Skippy | Master of a Ship | Unisex | American English |
| Sly | A forest | Unisex | Latin |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Sophia | Wisdom | Female | Greek |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Sprinkles | | Unisex | Hebrew |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Starlight | | Unisex | Hebrew |
| Stella | Star | Female | Latin |
| Stevie | Crown | Unisex | Greek |
| Suede | Swedish | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Suki | To like | Female | Japanese |
| Sushi | Raw fish. | Unisex | English |
| Sydney | Wide meadow | Female | English |
| Sylvia | Wooded | Female | Latin |
| Taffy | Beloved | Female | Welsh |