| Name | Meaning | Gender | Origin |
|---|
| Serrano | | Unisex | Hebrew |
| Shadow | Shadow | Unisex | English |
| Shania | Beautiful | Female | Yiddish |
| Shannon | God is gracious | Female | Hebrew |
| Shanta | The pacified | Female | Sanskrit |
| Shari | The plains | Female | Hebrew |
| Shasta | Name of a Native American tribe | Female | Native American |
| Shayla | Blind | Female | Latin |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sheri | The plains | Female | Hebrew |
| Shiloh | Gift for him | Unisex | Hebrew |
| Sidney | Wide meadow | Male | English |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Simon | Listening | Male | Hebrew |
| Skipper | Master of a Ship | Male | American English |
| Skippy | Master of a Ship | Unisex | American English |
| Skye | Cloud | Male | Norse |
| Slade | Valley | Male | English |
| Sly | A forest | Unisex | Latin |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Solomon | Peace | Male | Hebrew |
| Sophia | Wisdom | Female | Greek |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spencer | Someone who gives out goods | Male | French |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |