| Name | Meaning | Gender | Origin |
|---|
| Sara | Princess | Female | Hebrew |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Scout | Observer | Unisex | American English |
| September | From the month | Female | Latin |
| Shadow | Shadow | Unisex | English |
| Shamrock | | Unisex | Hebrew |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shorty | Of less than average size | Unisex | English |
| Sienna | Reddish orange-brown | Female | Italian |
| Simba | Lion | Female | Swahili |
| Slim | Slender in proportion to height. | Unisex | English |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sweet | | Unisex | Hebrew |
| Sweetie | Sweetheart. | Unisex | English |
| Sweetpea | | Unisex | Hebrew |
| Tasha | (Christ's) birthday | Female | Latin |
| Taylor | A tailor | Female | English |
| Tess | Harvester | Female | Greek |