| Name | Meaning | Gender | Origin |
|---|
| Sasha | Defending men | Unisex | Greek |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scar | From The Lion King | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sierra | Mountain range | Female | Spanish |
| Skeet | Swift | Male | English |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Soda | A carbonated water. | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Spade | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Spartacus | From the city of Sparta | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Stella | Star | Female | Latin |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sunshine | Light from the sun | Unisex | English |
| Talon | A claw | Male | English |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tanya | Princess | Female | Latin |
| Tara | Crag | Female | Gaelic |
| Tasha | (Christ's) birthday | Female | Latin |
| Tempest | Storm | Female | English |
| Tex | Of Texas | Unisex | English |
| Thor | Thunder | Male | Norse |
| Thunder | Stormy Tempered | Unisex | English |
| Titan | Powerful big man | Unisex | Greek |
| Titus | Of The Giants | Male | Latin |
| Tootsie | A girl or young woman. | Unisex | English |