| Name | Meaning | Gender | Origin |
|---|
| Slate | | Unisex | Hebrew |
| Slim | Slender in proportion to height. | Unisex | English |
| Sloane | Fighter | Unisex | American English |
| Sly | A forest | Unisex | Latin |
| Smudge | A blotch or smear | Unisex | English |
| Sniff | A short inhale through the nose. To savour or investigate a smell. | Unisex | English |
| Snoop | To pry into the private affairs of others | Unisex | English |
| Socks | Short stockings finishing above the ankle | Unisex | English |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Sprout | | Unisex | Hebrew |
| Spud | Slang for potato. | Unisex | English |
| Stitch | After the character in the Lilo And Stitch cartoon | Unisex | English |
| Styx | Myth Name (A River Of The Underworld) | Unisex | English |
| Sweet | | Unisex | Hebrew |
| Switch | | Unisex | Hebrew |
| Tai | Big | Unisex | Chinese |
| Tait | Cheerful | Unisex | Norse |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Taz | Wild Animal, Thrid Born | Unisex | American |
| Teal | The Bird Teal: Also The Blue-Green Color. | Unisex | English |
| Tex | Of Texas | Unisex | English |
| Tosh | Contentment | Unisex | Indian |
| Trace | Thracius' place | Unisex | English |
| True | Strength of the spear | Unisex | Germanic |
| Tuff | Fun spelling of tough; strong and resilient. | Unisex | English |
| Twix | Brand of chocolate bar. | Unisex | English |
| Ty | Abbreviation For Names Beginning With Ty-. | Unisex | American English |
| Val | To be healthy, strong | Unisex | Latin |