| Name | Meaning | Gender | Origin |
|---|
| Sampson | Sun | Unisex | Hebrew |
| Samson | Sun | Male | Hebrew |
| Sandy | Defending men | Male | Greek |
| Sanyu | Joyful | Unisex | African |
| Sarge | Noncommissioned Army or Air Force rank | Unisex | English |
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Saturn | Sixth and second largest planet away from the Sun. | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Sedona | | Unisex | Hebrew |
| Seiichi | Sincere one | Male | Japanese |
| Seiko | Sincere child | Unisex | Japanese |
| Shadow | Shadow | Unisex | English |
| Shark | | Unisex | Hebrew |
| Shiloh | Gift for him | Unisex | Hebrew |
| Shinichi | One truth | Male | Japanese |
| Shiori | Bookmark | Unisex | Japanese |
| Shoichi | First Son Of Sho | Male | Japanese |
| Shuichi | One lord | Male | Japanese |
| Silver | Silver (the metal or colour) | Male | English |
| Sky | Sky | Unisex | Norse |
| Sly | A forest | Unisex | Latin |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Smoky | | Unisex | Hebrew |
| Sparky | Animated, lively. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |