| Name | Meaning | Gender | Origin |
|---|
| Snuffles | | Unisex | Hebrew |
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Solomon | Peace | Male | Hebrew |
| Sonny | Son | Male | English |
| Spanky | | Unisex | Hebrew |
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Speed | Success | Unisex | English |
| Speedy | Rapid motion, swift. | Unisex | English |
| Spencer | Someone who gives out goods | Male | French |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Spud | Slang for potato. | Unisex | English |
| Spunky | Spirited, plucky. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Stanley | Meadow that is stony | Male | English |
| Sterling | Little star - stellar | Male | English |
| Stinky | | Unisex | Hebrew |
| Stormy | Violent weather | Unisex | English |
| Stuart | Gaurdian of the House | Male | English |
| Sundance | | Unisex | Hebrew |
| Sunday | 7th day of the week | Unisex | English |
| Sunny | Filled with sunlight | Male | English |
| Sunshine | Light from the sun | Unisex | English |
| Sweetie | Sweetheart. | Unisex | English |
| Sweetie-pie | | Unisex | Hebrew |
| Taco | A folded fried tortilla filled with meat, cheese and spices. | Unisex | English |
| Tango | | Unisex | Hebrew |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |