| Name | Meaning | Gender | Origin |
|---|
| Sassy | Lively and spirited | Unisex | English |
| Sawyer | One who saws wood | Male | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Scully | Town Crier | Male | English |
| Shadow | Shadow | Unisex | English |
| Shamus | Supplanter | Male | Hebrew |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Sherman | One who shears cloth | Male | English |
| Shilo | Gift for him | Unisex | Hebrew |
| Shirley | Bright grassland | Female | English |
| Silas | Of the forest | Male | Latin |
| Simba | Lion | Female | Swahili |
| Sloan | Fighter | Male | American English |
| Smoky | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Speranza | Hope | Female | Italian |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Stella | Star | Female | Latin |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Tad | Poet | Male | Gaelic |
| Tama | Jewel | Female | Japanese |
| Tango | | Unisex | Hebrew |
| Tao | Apple | Male | Vietnamese |
| Tasha | (Christ's) birthday | Female | Latin |
| Tavis | Twin | Male | Aramaic |