| Name | Meaning | Gender | Origin |
|---|
| Shelby | A place where willows grow | Female | American English |
| Shilo | Gift for him | Unisex | Hebrew |
| Shona | God is gracious | Female | Hebrew |
| Sienna | Reddish orange-brown | Female | Italian |
| Sierra | Mountain range | Female | Spanish |
| Sigma | | Unisex | Hebrew |
| Simba | Lion | Female | Swahili |
| Skittles | | Unisex | Hebrew |
| Sky | Sky | Unisex | Norse |
| Slipper | | Unisex | Hebrew |
| Smokie | | Unisex | Hebrew |
| Snowball | | Unisex | Hebrew |
| Snowflake | Single flake or crystal of snow. | Unisex | English |
| Sofia | Wisdom | Female | Greek |
| Sophie | Wisdom | Female | Greek |
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Sphinx | | Unisex | Hebrew |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spinner | | Unisex | Hebrew |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | English |
| Spud | Slang for potato. | Unisex | English |
| Star | Star | Female | Latin |
| Stardust | | Unisex | Hebrew |
| Starlight | | Unisex | Hebrew |
| Stella | Star | Female | Latin |
| Storm | Violent weather | Female | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Suki | To like | Female | Japanese |